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KMID : 0858420090110030149
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Korean Journal of Stroke
2009 Volume.11 No. 3 p.149 ~ p.152
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Predicting the Development of Infarction with 18F-Fluoromisonidazole Positron Emission Tomography in a Patient with Recurrent Transient Ischemic Attacks
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Kim Seung-Min
Lee Gha-Hyun
Sohn Ho-Yon
Kim Bum-Joon
Kwon Sun-Uck
Kang Dong-Wha
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Abstract
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In acute stroke, the target of reperfusion therapy is the severely hypoxic but salvageable tissue known as ischemic pen-umbra. A combination of perfusion weighted image (PWI) and diffusion-weighted magnetic resonance imaging has been recently used to delineate the ischemic penumbra, but PWI lesions usually include benign oligemic area and thereby overes-timate the hypoperfused tissues. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET), a newer penumbral imaging tool, can delineate hypoxic but viable tissue. Here, we report that a patient, who had recurrent transient ischemic attacks and high FMISO PET uptake in the right frontal cortex, later developed cerebral infarction in the same area of the PET abnormality. We suggest that FMISO PET may be useful in predicting the development of future infarction within the hemodynamically vulnerable area.
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KEYWORD
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Ischemic penumbra, Infarction, 18F-Fluoromisonidazole
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